Invanz ertapenem for injection for intravenous iv or intramuscular im use. For solution and drug compatibility information, see compatibility under stability. Guidelines recommend ertapenem for mixed necrotizing infections. Ertapenem is used alone or in combination with other antibiotics to treat. Provides a summary of interactions with vitamins, herbs, and food. Indications and dosages communityacquired pneumonia.
Stability of ertapenem 100 mgml in manufacturers glass vials or. Ertapenem medicare coverage and copay details goodrx. This drug is for the specified moderate to severe infections due to susceptible isolates of the designated microorganisms. Morphine sulfate, ropivacaine hydrochloride, and ziconotide. It works by killing bacteria or preventing their growth. Pharmacokinetics pk of ertapenem intravenous iv bolus. The carbapenem ertapenem is one of several firstline agents recommended by the infectious disease society of america for the empiric treatment of communityacquired intraabdominal infections of mildtomoderate severity. Ertapenem solution, reconstituted recon soln side effects by likelihood and severity common side effects if experienced, these tend to have a severe expression. I ran the abx on its own pump and connected it to the ysite on the heparin line. It is infused injected slowly intravenously over a period of at least 30 minutes once or twice a day for up to 14 days. Ertapenem is a 1beta methylcarbapenem which is chemically similar to beta lactams.
Invanz 1g powder for concentrate for solution for infusion. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4. This medication is known as a carbapenemtype antibiotic. Total and unbound fractions of ertapenem pharmacokinetics were investigated in 26 adult subjects 31 to 80 years of age with varying degrees of renal impairment. Intravenous compatibility chart free html5 flip book. Side effects of invanz ertapenem injection, warnings, uses. Ertapenem injection route description and brand names. Nov 15, 2019 compatibility of invanz with intravenous solutions containing heparin sodium and potassium chloride has been demonstrated. Invanz ertapenem dosing, indications, interactions.
Invanz ertapenemfor injection for intravenous iv or intramuscular im use initial u. Jun 22, 2010 pharmacokinetics pk of ertapenem intravenous iv bolus versus standard infusion the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Ertapenem is used to treat severe infections of the skin, lungs, stomach, pelvis, and urinary tract. Ertapenem injection comes as a powder to be mixed with liquid to be injected intravenously into a vein or intramuscularly into a muscle. Listing a study does not mean it has been evaluated by. Invanz ertapenem dose, indications, adverse effects. Following a single 1 g iv dose of ertapenem, the unbound auc increased 1. Intravenous admixtures preparation and infusion guidelines. Invanz, invanz addvantage ertapenem uses, side effects.
Ertapenem was reconstituted with sterile water for injection and then diluted with various commercial i. The reconstituted solutions should be inspected visually for particulate matter and discolouration prior to administration, whenever the container permits. By inhibiting cell wall synthesis, ertapenem has a bactericidal action. Ertapenem is used to treat a wide variety of bacterial infections. Antibiotic therapy should be administered until further debridement is not necessary, the patient has improved clinically, and fever has been absent for 48 to 72 hours. This medicine will not work for colds, flu, or other virus infections. In addition, new compatibility information is reported for these existing monographs. Ertapenem is injected into a muscle or into a vein through an iv. The king guide wall charts are a useful reference to have visible in the hospital and pharmacy for situations where a quick yes or no answer is needed. Urinary tract infections utis are common and important clinical problem in childhood, and extendedspectrumbetalactamase esbl producing organisms are the leading cause of healthcarerelated utis. Reserve use whenever possible, as it is one of our lastline antibiotics. Solutions of invanz range from colourless to pale yellow.
The king guide to parenteral admixtures is designed to help practitioners decide which alternative administration strategy is best. Colistimethate sodium with ertapenem, imipenemcilastatin sodium, linezolid, meropenem, piperacillin and tazobactam, and vancomycin hydrochloride. This medication is given by injection into a muscle or vein, usually once daily or as directed by your doctor. Ertapenem injection route description and brand names mayo.
Im sure there are plenty of reasons, but my choice would be that heparin needs to be a dedicated line so that people understand that its a critical drug that can cause death if not administered properly. Therefore this book should be used as guidance only. When administered intravenously, invanz should be infused over a period of 30 minutes. Administration of ertapenem 1 gram iv push over 5 minutes was. Dailymed invanz ertapenem sodium injection, powder. Ertapenem is used alone or in combination with other antibiotics to treat infections caused by bacteria in many different parts of the body. Intravenous iv preparation and infusion guidelines globalrph. Stability and compatibility of reconstituted ertapenem with commonly used i. One abx was vanco which is not compatible with heparin the other abx was azactam sp.
This reference contains standard dilutions including iv admixture drug concentration, infusion volumes, and infusion rates. Ertapenem is a 1betamethyl carbapenem and broadspectrum betalactam antibiotic with bactericidal property. Intravenous compatibility chart drug information for the. So today pt pt was ordered a heparin drip and iv abx. Substitutes and alternatives to invanz ertapenem for uses like colorectal surgical site infection prophylaxis, community acquired pneumonia and diabetic foot infection without osteomyelitis. Invanz ertapenem dosing, indications, interactions, adverse effects. This medication is given by injection into a muscle or vein, usually once. Ertapenem plasma levels were drawn and were noted to be 79. Ertapenem side effects, dosage, interactions drugs. Jan 24, 2020 1 g iv or im once a day for 3 to 10 days. It will not work for colds, flu, or other viral infections. Pharmacokinetics pk of ertapenem intravenous iv bolus versus standard infusion the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Ertapenem binds to penicillin binding proteins pbps located on the bacterial cell wall, in particular pbps 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall.
Aucs of total ertapenem and of unbound ertapenem are increased in patients who require haemodialysis approximately 2. Each monograph contains stability data, administration guidelines, and methods of preparation. Stability of ertapenem 100 mgml in manufacturers glass. These drugs have a broad spectrum of activity so are held in reserve for severe infections. It showed clinical activity in the treatment of obstetric and gynecological infections, skin and soft tissue infections, communityacquired pneumonia, urinary tract infections, and in. Common and rare side effects for ertapenem intravenous. Systemic and local adverse effects will be collected during the treatment and infection evolution will be described. Complicated urinary tract infections including pyelonephritis iv im q12hr up to 14 days. Stability and compatibility of reconstituted ertapenem with commonly. The clinical efficacy and safety of ertapenem for the. Reconstitute 1 g with 10 ml water for injections or sodium chloride 0.
Prophylactic administration of ertapenem as a single 1g iv dose has been. Its molecular formula is c22h24n3o7sna and mw is 497. Check out these bestsellers and special offers on books and. Previous studies of ertapenem stability have evaluated concentrations of 10 and 20 mgml following reconstitution and dilution in various iv infusion solutions and storage in various types of container. Ertapenem is administered via intravenous iv or intramuscular im routes. Sometimes they are serious, most of the time they are not. The stability of ertapenem sodium in various commonly used i. Surgical intervention is the primary therapeutic intervention. Do not selfinject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, syringes, iv tubing, and other items used to. Home explore intravenous compatibility chart drug information for the. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. In addition to updating drug interactions, precautions, alerts, and patient teaching. Patients over 75 receiving ertapenem for 48 hours iv or sc will be included. It is used to treat certain kinds of bacterial infections.
Agents with antipseudomonal activity, including doripenem, imipenem, and meropenem are not recommended in this population. Ertapenem invanz is a carbapenem and betalactam antibiotic that interferes with bacterial cell wall synthesis in susceptible pathogens. Invanz helps most people with infection, but it may have unwanted sideeffects in a few people. Ertapenem definition of ertapenem by medical dictionary. Feb, 2020 the first trial enrolled 404 patients and compared ertapenem 15 mgkg intravenous iv every 12 hours in patients 3 months to 12 years of age, and 1 g iv once a day in patients to 17 years of age to ceftriaxone 50 mgkgday iv in two divided doses in patients 3 months to 12 years of age and 50 mgkgday iv as a single daily dose in. Antiinfective pregnancy risk category b action inhibits cellwall synthesis in bacteria, causing cell death availability powder for infusion lyophilized. Do not selfinject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, syringes, iv tubing, and other items used to inject the medicine.
Ertapenem is a carbapenem antibiotic marketed by merck as invanz. In vitro it is active against anaerobes, gram positive and gram negative aerobic bacteria. The dose of invanz in patients years of age and older is 1 gram g given once a day. Ertapenem is a bacterial cell wall biosynthesis inhibitor with activity against a wide range of gramnegative and grampositive bacteria and resistance to a broad and extended spectrum of. A handbook for nurses and health professionals has been a trusted resource for comprehensive drug coverage, unparalleled accuracy, and an intuitive quickaccess format. The most common ertapenem related aes in previous studies were elevated hepatic transaminase levels 8. Ertapenem sodium is a synthetically derived, parenteral carbapenem antibiotic. The first trial enrolled 404 patients and compared ertapenem 15 mgkg intravenous iv every 12 hours in patients 3 months to 12 years of age, and 1 g iv once a day in patients to 17 years of age to ceftriaxone 50 mgkgday iv in two divided doses in patients 3 months to 12 years of age and 50 mgkgday iv as a single daily dose in. Pharmacokinetics of ertapenem in patients aged over 75. Information about drug ertapenem includes cost of the drug and the type of drug tablet, capsule, syrup, cream, gel, ointment, liquid or injection. Ertapenem injection invanz side effects, medical uses. Nov 09, 2018 ertapenem is an antibiotic that fights bacteria.
Indications, dose, contraindications, sideeffects, interactions, cautions, warnings and other safety information for ertapenem. With 122 iv drugs and 4 fluids the wall charts provide a comprehensive view of ysite compatibility for critical care admixtures and chemotherapy admixtures on a 27 x 27 wall chart. For the treatment of acute pelvic infections including postpartum endomyometritis, septic abortion, postsurgical gynecological infections due to streptococcus agalactiae, e coli, b fragilis, porphyromonas asaccharolytica, peptostreptococcus species, or prevotella bivia. Stability and compatibility of reconstituted ertapenem with. Ertapenem sodium dosage and administration administration. Ertapenem is used to prevent and treat a wide variety of bacterial infections. It exhibits nonlinear pharmacokinetics due to a high level of concentrationdependent plasma protein binding to albumin. To reduce the development of drugresistant bacteria and maintain the effectiveness of invanz and other antibacterial drugs, invanz should. When i looked its compatibility with heparin up it said it was compatible at the ysite. Switching to iv push, using solutions other than saline, using large volume solutions, or using syringe infusion pumps, may change the stability and compatibility characteristics of the medication to be. Aucs of total ertapenem and of unbound ertapenem are increased in patients with severe renal impairment cl cr 5 to 30 mlmin1. Heparin drip compatibilty patient medications allnurses.
The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. It is also may be given once or twice a day intramuscularly for up to 7 days. Ertapenem sodium reference guide for safe and effective use from the american society of healthsystem. Stability and compatibility of reconstituted ertapenem. Antibiotic drugs, information, description on ertapenem.
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